Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study
نویسندگان
چکیده
منابع مشابه
Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study
BACKGROUND Bleeding diathesis after aortic valve operation and ascending aorta replacement (AV-AA) is managed with fresh-frozen plasma (FFP) and platelet concentrates. The aim was to compare haemostatic effects of conventional transfusion management and FIBTEM (thromboelastometry test)-guided fibrinogen concentrate administration. METHODS A blood products transfusion algorithm was developed u...
متن کاملCRITICAL CARE Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study
Methods. A blood products transfusion algorithm was developed using retrospective data from 42 elective patients (Group A). Two units of platelet concentrate were transfused after cardiopulmonary bypass, followed by 4 u of FFP if bleeding persisted, if platelet count was 100 10 ml when removing the aortic clamp, and vice versa if platelet count was .100 10 ml. The trigger for each therapy step ...
متن کاملTheoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate
BACKGROUND We aimed to create a theoretical tool to model the effect of three haemostatic agents containing fibrinogen (therapeutic plasma, cryoprecipitate, and fibrinogen concentrate) on the patient's plasma fibrinogen level. METHODS A mathematical model was developed step-wise. The relationship between the amount of haemostatic agent and plasma fibrinogen level was plotted for each agent. A...
متن کاملFibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations.
BACKGROUND Patients experiencing massive haemorrhage are at high risk of developing coagulopathy through loss, consumption, and dilution of coagulation factors and platelets. It has been reported that plasma fibrinogen concentrations may reach a critical low level relatively early during bleeding, calling for replacement fibrinogen therapy. Cryoprecipitate has been widely used in the past, but ...
متن کاملStudies of platelet fibrinogen from a subject with a congenital plasma fibrinogen abnormality (fibrinogen Paris I).
Fibrinogen from normal platelets and plasma was compared with material derived from a subject with the congenital fibrinogen abnormality termed fibrinogen Paris I. The molecular abnormality in this subject is characterized by the presence (in plasma molecules) of relatively large mutant ‘y-chains (‘y-Paris I) that replace 50% or more of the normal “y-chain population and that, unlike normal ‘y-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2009
ISSN: 0007-0912
DOI: 10.1093/bja/aep089